Cookie Img Back to top
   Call Me Free Offline Send SMS Send Inquiry
Home » Products » Active Pharmaceutical Ingredients » Glimepiride

Glimepiride

Glimepiride
Glimepiride
Send Inquiry
Product Code : 16
Brand Name : MEDICA PHARMA CHEM
Product Description

Glimepiride (93479-97-1)

CAS No:

93479-97-1

AHFS Codes:

68:20.20

Synonyms:

Glimepirid, Glimepirida, Glimepiridum, Glimepride

ATC code:

A10BB12

Molecular Weight:

490.616 g/mol

PubChem:

CID 3476

Chemical Formula:

C13H15NO2

DrugBank:

DB00222 (APRD00381)

Assay/Purity:

Typically NLT 98%

IUPAC Name:

3-ethyl-4-methyl-N-{2-[4-({[(4-methylcyclohexyl)carbamoyl]amino}sulfonyl)phenyl]ethyl}-2-oxo-2,5-dihydro-1H-pyrrole-1-carboxamide

SMILES:

CCC1=C(C)CN(C(=O)NCCC2=CC=C(C=C2)S(=O)(=O)NC(=O)NC2CCC(C)CC2)C1=O

InChl:

WIGIZIANZCJQQY-UHFFFAOYSA-N

Indication:

For concomitant use with insulin for the treatment of noninsulin-dependent (type 2) diabetes mellitus.

Pharmacodynamics:

Glimepiride, like glyburide and glipizide, is a "second-generation" sulfonylurea agents. Glimepiride is used with diet to lower blood glucose by increasing the secretion of insulin from pancreas and increasing the sensitivity of peripheral tissues to insulin.

Mode of Action:

The mechanism of action of glimepiride in lowering blood glucose appears to be dependent on stimulating the release of insulin from functioning pancreatic beta cells, and increasing sensitivity of peripheral tissues to insulin. Glimepiride likely binds to ATP-sensitive potassium channel receptors on the pancreatic cell surface, reducing potassium conductance and causing depolarization of the membrane. Membrane depolarization stimulates calcium ion influx through voltage-sensitive calcium channels. This increase in intracellular calcium ion concentration induces the secretion of insulin.

Metabolism:

Hepatic. Following either an intravenous or oral dose, glimepiride is completely metabolized by oxidative biotransformation to a major metabolite, cyclohexyl hydroxymethyl derivative (M1), via the hepatic cytochrome P450 II C9 subsystem. M1 is further metabolized to the carboxyl derivative (M2) by one or several cytosolic enzymes. M1, but not M2, possessed approximately one third of the pharmacologic activity of its parent in an animal model. However, whether the glucose-lowering effect of M1 is clinically significant is not clear.

Toxicity:

Severe hypoglycemic reactions with coma, seizure, or other neurological impairment.

Trade Information
  • Payment Terms
  • Others, Cheque
  • Delivery Time
  • as per products Days
  • Sample Available
  • Yes
  • Sample Policy
  • Contact us for information regarding our sample policy
  • Packaging Details
  • Standard
  • Main Domestic Market
  • All India

MEDICA PHARMA CHEM
X


Contact Details

MEDICA PHARMA CHEM
207, Shivalik Plaza, Kapodara, Surat - 394105, Gujarat, India
Mr. Kishan S Nakarani (Proprietor)
   Call Me Free Offline Send SMS Send Inquiry
Trust Stamp
Product Showcase